Amino Acid Substitution Rates

Familial Porphyria Cutanea Tarda: Characterization of Seven Novel Uroporphyrinogen Decarboxylase Mutations and Frequency of Common Hemochromatosis Alleles

Argentina / Heterogeneity / Biological Sciences / Genetic counseling / Humans / Mutation / Polymerase Chain Reaction / Exploration / Pigments / Pigment / Photosensitivity / Long Range / Genetic determinism / Skin / Gene / Phenotype / Hemochromatosis / Introns / Risk Factor / Gen / Genotype / Uroporphyrinogen Decarboxylase / Base Sequence / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Haplotype / The American / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Exploration / Pigments / Pigment / Photosensitivity / Long Range / Genetic determinism / Skin / Gene / Phenotype / Hemochromatosis / Introns / Risk Factor / Gen / Genotype / Uroporphyrinogen Decarboxylase / Base Sequence / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Haplotype / The American / Molecular Sequence Data

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Familial Porphyria Cutanea Tarda: Characterization of Seven Novel Uroporphyrinogen Decarboxylase Mutations and Frequency of Common Hemochromatosis Alleles

Argentina / Heterogeneity / Biological Sciences / Genetic counseling / Humans / Mutation / Polymerase Chain Reaction / Exploration / Pigments / Pigment / Photosensitivity / Long Range / Genetic determinism / Skin / Gene / Phenotype / Hemochromatosis / Introns / Risk Factor / Gen / Genotype / Uroporphyrinogen Decarboxylase / Base Sequence / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Haplotype / The American / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Exploration / Pigments / Pigment / Photosensitivity / Long Range / Genetic determinism / Skin / Gene / Phenotype / Hemochromatosis / Introns / Risk Factor / Gen / Genotype / Uroporphyrinogen Decarboxylase / Base Sequence / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Haplotype / The American / Molecular Sequence Data

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Biochemical characterization of recombinant serotonin N-acetyltransferase

Engineering / Biochemistry / Thermodynamics / Technology / Catalysis / Kinetics / Virology / Calcium / Biological Chemistry / HIV / Aspergillus / Biological Sciences / Saccharomyces cerevisiae / PCR / Ubiquitin / Plant Genome Project / Tuberculosis / Humans / Sequence alignment / Mycobacterium tuberculosis / Escherichia coli / Mice / CPM / Female / Animals / Male / Glutathione / Physical sciences / Candida albicans / Phosphorylation / Proteins / Capsid / Affinity chromatography / SALT TOLERANCE / Enzyme / Casein Kinase 2 / Cattle / Molecular cloning / Rats / HeLa cells / Substrate Specificity / Pineal / Protein Conformation / Protein Kinase / Amino Acid Sequence / Base Sequence / Ribonucleoproteins / Amino Acid Substitution Rates / Recombinant Protein / Recombinant Proteins / Biological Macromolecules / Hydrogen-Ion Concentration / Asparagine / Fusion Protein / DNA binding proteins / Site-directed Mutagenesis / Sodium Chloride / Biochemistry and cell biology / Dimerization / Okadaic acid / Molecular Sequence Data / DNA mutational analysis / Kinetics / Virology / Calcium / Biological Chemistry / HIV / Aspergillus / Biological Sciences / Saccharomyces cerevisiae / PCR / Ubiquitin / Plant Genome Project / Tuberculosis / Humans / Sequence alignment / Mycobacterium tuberculosis / Escherichia coli / Mice / CPM / Female / Animals / Male / Glutathione / Physical sciences / Candida albicans / Phosphorylation / Proteins / Capsid / Affinity chromatography / SALT TOLERANCE / Enzyme / Casein Kinase 2 / Cattle / Molecular cloning / Rats / HeLa cells / Substrate Specificity / Pineal / Protein Conformation / Protein Kinase / Amino Acid Sequence / Base Sequence / Ribonucleoproteins / Amino Acid Substitution Rates / Recombinant Protein / Recombinant Proteins / Biological Macromolecules / Hydrogen-Ion Concentration / Asparagine / Fusion Protein / DNA binding proteins / Site-directed Mutagenesis / Sodium Chloride / Biochemistry and cell biology / Dimerization / Okadaic acid / Molecular Sequence Data / DNA mutational analysis

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Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in Vitro

Bacteriology / Catalysis / Flow Cytometry / Virology / Calcium / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data

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Identification of amino acid residues critical for endonuclease and integration activities of HIV1 IN protein in Vitro

Bacteriology / Catalysis / Flow Cytometry / Virology / Calcium / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Biological / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Biological / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma

Cancer / Treatment / Prevention / Cancer Vaccines / Humans / Mice / Female / Animals / Vaccination / Efficiency / Neuroblastoma / Molecular Mimicry / Spot / Substitution / Amino Acid Substitution Rates / Gangliosides / immunoglobulin G / Mice / Female / Animals / Vaccination / Efficiency / Neuroblastoma / Molecular Mimicry / Spot / Substitution / Amino Acid Substitution Rates / Gangliosides / immunoglobulin G

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Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation

Biological Sciences / Cell line / Humans / Kidney / Calcium channels / Phosphorylation / Biochemical / Mitogen Activated Protein Kinase / CHEMICAL SCIENCES / Amino Acids / Phenylalanine / Amino Acid Substitution Rates / Recombinant Proteins / Allosteric regulation / Phosphorylation / Biochemical / Mitogen Activated Protein Kinase / CHEMICAL SCIENCES / Amino Acids / Phenylalanine / Amino Acid Substitution Rates / Recombinant Proteins / Allosteric regulation

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Transpecific polymorphisms in an inversion linked esterase locus in Drosophila buzzatii

Evolutionary Biology / Genetics / Polymorphism / Gene Flow / In Situ Hybridization / Natural Selection / DNA / Drosophila / Sequence alignment / Animals / Polymerase Chain Reaction / Molecular biology and evolution / Gene Conversion / Genetic linkage analysis / Balancing selection / Genetic Differentiation / Genetic Recombination / Genetic variation / Base Sequence / Amino Acid Substitution Rates / Neutral Theory / Nucleotide Polymorphism / Nucleotides / Biochemistry and cell biology / Molecular Sequence Data / Natural Selection / DNA / Drosophila / Sequence alignment / Animals / Polymerase Chain Reaction / Molecular biology and evolution / Gene Conversion / Genetic linkage analysis / Balancing selection / Genetic Differentiation / Genetic Recombination / Genetic variation / Base Sequence / Amino Acid Substitution Rates / Neutral Theory / Nucleotide Polymorphism / Nucleotides / Biochemistry and cell biology / Molecular Sequence Data

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Sequence comparison and environmental adaptation of a bacterial endonuclease

Computational Biology / Molecular Evolution / Statistical Analysis / Brackish Water / Sequence Analysis / Biological Sciences / Sequence alignment / Bacteria / Temperature / Sample Size / Enzyme / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Model System / Surface Properties / Low Temperature / Protein Conformation / Amino Acid Sequence / Amino Acid Substitution Rates / Salts / Biology Chemistry / Protein Data Bank / Isoelectric point / Biological Sciences / Sequence alignment / Bacteria / Temperature / Sample Size / Enzyme / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Model System / Surface Properties / Low Temperature / Protein Conformation / Amino Acid Sequence / Amino Acid Substitution Rates / Salts / Biology Chemistry / Protein Data Bank / Isoelectric point

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Multiple Endocrine Neoplasia Type1: An Unusual Presentation

Genetics / Molecular Biology / Surgical Oncology / Gene expression / Macromolecular X-Ray Crystallography / Biological Sciences / Humans / Mutagenesis / Genetic Testing / Mutation / Mice / Female / Animals / Male / Gene / Pedigree / Risk factors / Phenotype / Insulinoma / Clinical Sciences / Molecular cloning / Gen / Genotype / Adult / Pituitary Adenoma / Disease Progression / Risk Factors / Hyperparathyroidism / Primary hyperparathyroidism / Amino Acid Substitution Rates / X ray Computed Tomography / Adenoma / Endocrinologist / Hypercalcemia / Pituitary Neoplasms / Biological Sciences / Humans / Mutagenesis / Genetic Testing / Mutation / Mice / Female / Animals / Male / Gene / Pedigree / Risk factors / Phenotype / Insulinoma / Clinical Sciences / Molecular cloning / Gen / Genotype / Adult / Pituitary Adenoma / Disease Progression / Risk Factors / Hyperparathyroidism / Primary hyperparathyroidism / Amino Acid Substitution Rates / X ray Computed Tomography / Adenoma / Endocrinologist / Hypercalcemia / Pituitary Neoplasms

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Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis

Mass Spectrometry / Multidisciplinary / Amyotrophic Lateral Sclerosis / Humans / Mutation / Differential scanning calorimetry / Superoxide Dismutase / Metals / Glass Transition Temperature / Amino Acid Substitution Rates / Transition Temperature / Differential scanning calorimetry / Superoxide Dismutase / Metals / Glass Transition Temperature / Amino Acid Substitution Rates / Transition Temperature

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Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis

Biochemistry / Catalysis / Kinetics / Enzyme Inhibitors / Humans / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data

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HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway

Neurochemistry / Enzyme Inhibitors / Signal Transduction / Humans / Reactive Oxygen Species / Phosphorylation / Mitogen Activated Protein Kinase / NADPH oxidase / Neuroblastoma / Transfection / Amino Acid Substitution Rates / Neurosciences / Oxidation-Reduction / Superoxides / Protein Transport / Cell Membrane / Phosphorylation / Mitogen Activated Protein Kinase / NADPH oxidase / Neuroblastoma / Transfection / Amino Acid Substitution Rates / Neurosciences / Oxidation-Reduction / Superoxides / Protein Transport / Cell Membrane

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HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway

Neurochemistry / Enzyme Inhibitors / Signal Transduction / Humans / Reactive Oxygen Species / Phosphorylation / Mitogen Activated Protein Kinase / NADPH oxidase / Neuroblastoma / Transfection / Amino Acid Substitution Rates / Neurosciences / Oxidation-Reduction / Superoxides / Protein Transport / Cell Membrane / Phosphorylation / Mitogen Activated Protein Kinase / NADPH oxidase / Neuroblastoma / Transfection / Amino Acid Substitution Rates / Neurosciences / Oxidation-Reduction / Superoxides / Protein Transport / Cell Membrane

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